Regenerative Skin Booster · Polynucleotide
Rejuran in Seoul — Sessions, Downtime & Pricing
Polynucleotide Skin Repair & Barrier Recovery
- Duration
- 20-30 min (full face); 10-15 min (periorbital or lip)
- Sessions
- 3 induction (2-4 wk apart); maintenance 1 / 3-6 months
- Downtime
- 24-48 hours visible papules
Rejuran Treatment in Seoul
Rejuran polynucleotide skin booster at Delight Dermatology in Gangnam — a regenerative injectable for skin texture, fine lines, and post-procedure recovery, with board-certified dermatologist consultation.
- Duration
- 20–30 min full face / 10–15 min periorbital or lip
- Sessions
- 3 induction (2–4 wk); maintenance 1 / 3–6 months
- Downtime
- 24–48 hours visible papules
- Peak Result
- Week 8–12 after full induction
Results Over Time
Rejuran is a regenerative skin booster for texture, fine lines, and barrier quality. The active ingredient is highly-purified polynucleotide (PN) from salmon DNA, made by Korea's PharmaResearch.
01During injection
Micro-injections are placed across the area. Topical anesthesia is usually applied to reduce discomfort.
02Day 0
Visible papules at injection sites. Mild swelling and redness.
03Day 1–2
Papules flatten. Makeup is typically resumed on Day 2.
04Week 4 (sessions 1–2)
Texture and barrier improvement becomes visible.
05Week 8–12 (full course)
Peak effect. Maintenance every 3–6 months is commonly recommended.
Images are AI-generated for illustrative purposes only.
Rejuran Polynucleotide
Rejuran (PharmaResearch) is a polynucleotide (PN) regenerative skin booster — an MFDS-approved Class IV device in Korea — that repairs skin quality rather than adding volume.
Polynucleotide (PN)
Highly-purified PN from salmon DNA stimulates regeneration — improving texture, elasticity, and barrier, without adding volume.
Variant Range
Healer (texture), HB / HB Plus (hydration + lidocaine), Eye (under-eye), and S (scar) — matched to your concern.
Gentle Regeneration
Minimal pain and downtime versus laser; a regenerative rather than space-filling approach.
Treatment Process
01Clinical Evaluation
The dermatologist evaluates the concern, depth of wrinkle/scar, and history — including known fish or salmon allergy.
02Variant Selection
A Rejuran variant is selected — Healer (texture), HB (hydration hybrid), HB Plus (lidocaine, periorbital), Eye (under-eye), or S (scar).
03Injection Planning
Topical anesthesia is applied; an intradermal microbolus plan is mapped (≤0.05 mL per point at 0.5–1 cm spacing).
04Procedure
A session typically takes 20–30 minutes full face; periorbital or lip sessions are shorter. Induction = 3 sessions at 2–4 week intervals.
Treatment Results
Clinical photographs. Individual results vary with skin condition, age, and treatment plan.
Recovery & Care
First 24–48h
No touching, hot showers, saunas, or exercise. Papules are normal — do not pick.
Day 3–7
Resume normal skincare. Avoid retinoids until skin settles. SPF 50+.
Week 2–4
Strict sun protection. Schedule the next session.
Long-term
Daily SPF 50+. Discuss combination protocols with your dermatologist.
Frequently Asked Questions
Q.Is Rejuran FDA-approved?
Not as an injectable in the United States. Rejuran is MFDS-approved as a Class IV medical device in Korea (original Healer 2014, HB Plus 2021) and CE-marked in the EU. Topical PDRN-branded cosmetics may be sold under FDA cosmetic regulation in the US but are separate products from the injectable medical device. Honest regulatory framing is part of board-certified Anti-Aging specialist standards.
Q.How is Rejuran different from JUVELOOK, Sculptra, or HA fillers?
All four work on different layers and pathways. Rejuran (polynucleotide / PN) is a regenerative biostimulator — adenosine A2A receptor signaling + nucleotide salvage — that improves skin quality without adding volume. JUVELOOK (PDLLA + HA hybrid) and Sculptra (PLLA) stimulate fibroblast-driven collagen over months for structural support. HA fillers add immediate volume via space-occupying gel. Korean clinical practice routinely combines them at different sessions or depths for layered effect; selection depends on whether the concern is texture (Rejuran), structure (PDLLA/PLLA), or volume (HA).
Q.How many sessions and how soon will I see results?
Standard induction is 3 sessions at 2-4 week intervals. Skin texture changes typically become visible between session 2 and 3, with continued improvement 4-8 weeks after the last session. Maintenance is commonly cited at every 3-6 months but is not standardized in published trials.
Q.Does Rejuran completely remove acne scars?
No. The strongest available Rejuran-specific acne-scar evidence — Araco 2021 RCT — demonstrated significant improvement on Antera 3D imaging at 1 and 3 months versus placebo, but the trial was small and explicitly preliminary. Rejuran is best understood as an adjunct to fractional CO2 laser, subcision, or TCA CROSS — not as monotherapy for moderate-to-severe scarring.
Q.Is the procedure painful?
Yes — intradermal microbolus injection is genuinely uncomfortable. Topical anesthetic is standard. The HB Plus formulation includes lidocaine to reduce pain, which is why it is preferred for periorbital and full-face protocols. Honest framing: published Rejuran trials report transient injection-site pain in 90%+ of patients, with mild and short-lived swelling and erythema.
References5
The clinical claims on this page — device specs, efficacy timelines, safety profile — are supported by the primary sources below. Each citation links to the original paper or regulatory record.
- [1]Polynucleotides in Esthetic Medicine: A Systematic Review. J Cosmet Dermatol (Lampridou et al.) — systematic review, 9 studies, N=219 (2024).
- [2]Randomized Split-Face: Polycaprolactone vs Polynucleotide for Crow's Feet. J Cosmet Dermatol (Jeong et al.) — split-face RCT N=30, 12-week comparable efficacy (2019).
- [3]Highly Purified Polynucleotide vs Placebo for Atrophic Acne Scars. Aesthet Surg J (Araco & Araco) — double-blind RCT N=20 (2021).
- [4]Expert Perspectives on Polynucleotides in Aesthetic Medicine. Clin Cosmet Investig Dermatol (Rho et al.) — expert panel review (PharmaResearch co-authors) (2026).
- [5]Polydeoxyribonucleotide as a Wound-Healing Platform. Pharmaceuticals (Galeano et al.) — 25-year pharmacology review (2021).
Notice
- Active skin infection or inflammation at injection site
- Known hypersensitivity to polynucleotide or salmon-derived products
- Active autoimmune connective tissue disease (relative — requires dermatologist review)
- Active bleeding diathesis or recent anticoagulant use without physician clearance
- Pregnancy or lactation (no efficacy/safety data — elective procedure deferred)
- Recent (within 4 weeks) injection of permanent filler in the same area (relative)
- Keloid-prone patients in atrophic-scar protocols (relative)
Session summary & comparison
| Item | Details |
|---|---|
| Treatment time | about 20-30 minutes |
| Pain & comfort | Intradermal micro-injections are genuinely uncomfortable; topical anaesthetic is standard, and the HB Plus formulation contains lidocaine to reduce pain |
| Downtime | Minimal — mild bumps and minor bruising settle within 24-48 hours |
| Course & onset | Standard induction is 3 sessions 2-4 weeks apart; texture change is usually visible between the second and third session, fullest about 1 month after the course |
| Maintenance | Roughly every 3-6 months, based on how your skin responds |
Related procedures
Evidence & comparison guides
- Sculptra vs Skin Boosters Seoul | Evidence-Based Guide
- Dermatology Downtime Guide Seoul | Recovery Timelines
- Same-Day Dermatology Seoul | Consult & Treat in One Visit
- Polynucleotide (Rejuran / PDRN) Skin Boosters Seoul: 2026 Evidence
- Sculptra Master, Thermage TTT & Rejuran VIP Certifications
- Why Hand Technique Decides Your Injectable Outcome (2026 Review)
Notice: Individual results may vary depending on skin condition, treatment history, and recovery factors. All treatment plans are determined through individual consultation with a board-certified dermatologist. The information on this page is for reference only and does not constitute medical advice or guarantee specific outcomes.
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