Allergan Aesthetics · FDA-Approved 2023

SKINVIVE by JUVÉDERM in Seoul | FDA-Approved Skin Quality Injectable

SKINVIVE by JUVÉDERM is the first and only hyaluronic acid microdroplet injectable FDA-approved (May 2023) to improve skin smoothness of the cheeks. Manufactured by Allergan Aesthetics (AbbVie), it creates an entirely new category — sitting distinctly between traditional skinboosters and conventional dermal fillers. The pivotal US clinical trial (N=209) showed 57.9% of treated participants achieved at least a 1-point improvement in cheek smoothness at 1 month, with effects sustained through 6 months. Its mechanism involves Aquaporin-3, a protein that facilitates water and glycerol movement in the skin, enhancing intradermal hydration from within.

Reviewed by Dr. SangYoul Yun

Board-certified Dermatologist · Chief Director · AAD Member

Overview

SKINVIVE by JUVÉDERM in Seoul — manufactured by Allergan Aesthetics (AbbVie). FDA-approved in May 2023 as the first HA microdroplet injectable indicated for cheek smoothness improvement.

Best for

Dull, dehydrated skin lacking natural glow
Rough skin texture on the cheeks
Desire for a single treatment with multi-month results
Seeking an FDA-approved skin quality product

Suited for

Patients wanting long-lasting skin hydration (3-6 months)
Those preferring an FDA-approved product for skin quality improvement
International visitors wanting sustained results from one visit
Patients who find monthly skin boosters inconvenient

Duration: 20-30 min
Sessions: 1 every 3-6 months
Downtime: Minimal (24-48 hr mild bumps)
Peak result: 1 month

Timeline

Immediately post
Small injection papules and mild redness visible; typically resolve within 24-48 hours.
Days 1-2
Faint bumps and mild tenderness may persist; most patients cover with makeup from day 2.
Week 1
Injection marks fully settle; early smoothness and hydration benefits become apparent.
1 month
Peak measured improvement in cheek smoothness per the FDA pivotal trial (P220046).
3-6 months
Skin quality benefits sustained through 6 months in clinical trial; gradual return to baseline thereafter.

Devices

SKINVIVE by JUVÉDERM

Allergan Aesthetics (AbbVie)FDA-approved PMA P220046 (May 2023)

Key specs

: Hyaluronic acid (HA) microdroplet injectable
: First and only HA product FDA-approved for cheek skin smoothness (not volumizing)
: Vycross™ cross-linking technology (Allergan proprietary)
: Intradermal microdroplet placement — distinct from traditional filler depth
: Mechanism engages Aquaporin-3 to enhance intradermal water/glycerol movement
Typical treatment: 2-4 syringes per session (dermatologist-adjusted)
: Effects sustained through 6 months from a single session

Process

01
Dermatologist evaluates skin quality and hydration needs
02
SkinVive micro-droplets are injected into the cheeks using a fine needle
03
Treatment covers both cheeks in approximately 15-20 minutes
04
Results are immediate with continued improvement over 2-4 weeks

Aftercare

01First 24 hours
Avoid vigorous exercise, alcohol, and heat exposure (saunas, hot showers) to minimize bruising and swelling.
02Days 2-3
Makeup may be applied once injection marks settle; use gentle cleansers. Avoid massage of the treated area.
03Week 1
Continue daily broad-spectrum SPF 30+. Resume normal skincare and exercise.
046-month maintenance
Effects sustained through ~6 months per clinical trial; schedule maintenance at 4-6 months for continuous benefit.

FAQ

Is SkinVive the same as Juvéderm filler?

No. SkinVive is a different product formulated specifically for skin quality improvement, not volumizing. It uses a modified HA formulation designed for micro-droplet injection into the skin.

How long does SkinVive last?

Clinical studies show results lasting up to 6 months from a single treatment. Most patients report noticeable improvement for 3-6 months.

Notice

Tell the dermatologist at consultation if any of the following apply.

Active skin infections or open wounds in the target area
History of severe or multiple allergies / anaphylaxis
Known hypersensitivity to hyaluronic acid or gram-positive bacterial proteins
Bleeding disorders or use of anticoagulants without physician clearance
Pregnancy or breastfeeding (not studied — avoid as precaution)

For your visit

Minimal downtime — mild redness and small bumps resolve within 24-48 hours
Avoid heavy exercise and alcohol for 24 hours
Results last 3-6 months from a single treatment session

References

The clinical claims on this page — device specs, efficacy timelines, safety profile — are supported by the primary sources below. Each citation links to the original paper or regulatory record.

[1]SKINVIVE by JUVÉDERM Premarket Approval (P220046). U.S. Food & Drug Administration (PMA P220046) (2023).

Reviewed byDr. SangYoul Yun· Board-Certified Dermatologist · AAD International Fellow (IFAAD)· Last reviewed 2026-04-21

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Notice: Individual results may vary depending on skin condition, treatment history, and recovery factors. All treatment plans are determined through individual consultation with a board-certified dermatologist. The information on this page is for reference only and does not constitute medical advice or guarantee specific outcomes.

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