ECM Booster · hADM
Elravie Re2O
Re2O is the 4th generation of skin boosters — the only injectable that replenishes real human extracellular matrix (hADM) directly into the dermis, rather than stimulating the skin to produce collagen indirectly. Launched in 2024 by Humedix, it is processed with patented AlloClean technology to remove all cellular and lipid fractions that could trigger immune response.
Board-Certified
Dermatologist
AAD International Fellow
IFAAD
FDA-cleared
Where applicable
MFDS-registered
Korean MoH&W
Overview
Elravie Re2O in Seoul — the world's first ECM booster using human-derived dermal matrix (hADM) from Humedix Korea for direct structural skin restoration.
Best for
- Skin aging with visible ECM structural loss — laxity, thinning, crepey texture
- Plateau after conventional PN (Rejuran) or HA boosters
- Post-procedure recovery after RF microneedling, laser, or HIFU
- Periorbital and delicate zones where structural rebuilding is preferred over volume
Suited for
- Patients who have plateaued with PN or HA boosters
- Those seeking natural, gradual skin quality improvement without volumization
- Patients recovering from energy-based procedures (RF, laser, HIFU) who want accelerated barrier repair
- Mid-30s and older patients with dermal thinning and ECM-driven laxity
Process
01
Dermatologist evaluates skin density, ECM loss pattern, and treatment goals
02
Topical anesthesia is applied; injection plan is mapped for serial puncture, linear threading, or cannula in delicate zones
03
hADM microparticles (150 mg) are injected into the deep dermis across the treatment area
04
Session takes approximately 20-30 minutes
05
Papules and mild embossing resolve within 2-3 days; makeup from the following day
“Injectables and energy devices are performed by physicians — never delegated to non-physician staff. The clinic is led by a board-certified dermatologist.”
FAQ
How is Re2O different from Rejuran, Juvelook, or regular HA boosters?
Re2O is the 4th generation — it directly replenishes extracellular matrix using human-derived hADM. Rejuran (2nd gen, salmon PDRN) and Juvelook (3rd gen, PDLLA) stimulate the skin to produce collagen indirectly. HA boosters (1st gen) provide immediate hydration only. Re2O is the first to rebuild the actual structural matrix of the dermis rather than triggering a stimulation pathway.
Is hADM safe? It comes from human tissue.
The hADM raw material has FDA approval and has been used for years in surgical tissue reconstruction before its aesthetic application. Patented AlloClean technology removes all cellular and lipid fractions that could trigger immune or rejection responses, leaving a pure, acellular ECM scaffold. Because ECM naturally exists in the human body, the skin recognizes Re2O as 'self' — not as a foreign implant.
How soon can I see results?
The injected ECM provides immediate physical scaffolding — you may see skin density and texture improvement after a single session. As the matrix gradually degrades over weeks, it signals fibroblast activation and new collagen/elastin synthesis. Peak results are typically observed at 4-8 weeks, with clinical studies confirming sustained elasticity improvement after a 3-session course.
For your visit
- Minimal downtime — papules and embossing resolve within 2-3 days; bruising (if any) within 1-2 days
- Cleansing from 3 hours post-procedure; makeup from the following day
- Immediate structural improvement; peak results at 4-8 weeks; 3 sessions at 3-4 week intervals for optimal outcome
Related procedures
Notice: Individual results may vary depending on skin condition, treatment history, and recovery factors. All treatment plans are determined through individual consultation with a board-certified dermatologist. The information on this page is for reference only and does not constitute medical advice or guarantee specific outcomes.
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