Submental Fat Reduction · MFDS-Approved

V-OLET

V-OLET is an MFDS-approved Korean submental fat reduction injectable, mechanistically similar to Kybella (ATX-101) in the US. Its active ingredient, deoxycholic acid (DCA), is a secondary bile acid naturally produced in the body that emulsifies fat cell membranes. Unlike conventional lipolytic injections that merely shrink fat cells, V-OLET destroys them and triggers neocollagenesis for simultaneous skin tightening.

Board-Certified

Dermatologist

AAD International Fellow

IFAAD

FDA-cleared

Where applicable

MFDS-registered

Korean MoH&W

Reviewed personally by Dr. SangYoul Yun

Board-certified Dermatologist · AAD International Fellow (IFAAD) · IFAAD-verified

Overview

V-OLET is an MFDS-approved injectable for submental fat reduction in Korea — deoxycholic acid that destroys fat cells and simultaneously induces collagen synthesis.

Best for

Moderate to severe submental fat (double chin) unresponsive to diet or exercise
Blurred jawline and indistinct cervicomental angle
Residual submental fat after weight loss
Insufficient chin definition despite botulinum toxin treatment

Suited for

Patients with true double chin anatomy seeking permanent fat reduction without surgery
Those wanting jawline definition plus the skin-tightening effect of collagen induction
Post-weight-loss patients with residual submental fat compartments
International visitors prepared for 1-3 weeks of post-treatment swelling

Duration: 20-30 min
Sessions: 3-5 at 4-wk intervals
Downtime: 1-3 weeks swelling
Peak result: 4-8 weeks post-course

Timeline

Days 0-3
Significant swelling, tenderness, and possible bruising in the submental area — expected from fat cell destruction.
Weeks 1-3
Swelling subsides gradually. Numbness or firmness under the chin can persist briefly.
Weeks 4-8
Visible submental fat reduction and skin tightening develop per session.
After full course
Durable jawline definition — destroyed fat cells do not return absent significant weight gain.

Devices

V-OLET (deoxycholic acid)

Operator confirm — MFDS-licensed Korean deoxycholic acid injectableMFDS-approved deoxycholic acid for submental fat reduction

Key specs

Active ingredient: deoxycholic acid, a naturally occurring secondary bile acid
Mechanism: adipocytolysis — permanently destroys fat cells, then triggers neocollagenesis
Injection: subcutaneous into submental fat under ultrasound guidance
Protocol: 3-5 sessions spaced 4 weeks apart
Expected swelling: 1-3 weeks — an expected biological response, not a complication
Durability: destroyed fat cells do not regenerate

Process

01
Dermatologist evaluates submental fat distribution, skin elasticity, and anatomy with ultrasound guidance
02
Treatment zone is mapped precisely to protect surrounding nerves and vessels
03
Deoxycholic acid is injected into the targeted submental fat compartment under ultrasound guidance
04
Session takes approximately 20-30 minutes
05
Visible submental reduction and skin tightening develop progressively over 4-8 weeks

“Injectables and energy devices are performed by physicians — never delegated to non-physician staff. The clinic is led by a board-certified dermatologist.”
— Dr. SangYoul Yun · Clinic Director · Board-Certified Dermatologist · AAD IFAAD

Aftercare

First week
Avoid heat (sauna, hot baths), strenuous exercise, and alcohol. Cold compress eases swelling.
Weeks 1-3
Swelling is expected and resolves gradually. A chin compression strap may help comfort.
Between sessions
Sessions are spaced 4 weeks apart; the dermatologist reassesses fat distribution each visit.
Long-term
Maintain stable weight — remaining fat cells can enlarge with significant weight gain.

FAQ

How is V-OLET different from conventional lipolytic injections (known in Korea as 윤곽주사)?

V-OLET performs adipocytolysis — it permanently destroys fat cells so they cannot regrow. Conventional lipolytic injections only temporarily reduce fat cell size. V-OLET also induces neocollagenesis, producing simultaneous skin tightening. It is the only MFDS-approved deoxycholic acid product for submental fat reduction in Korea, with Korean clinical trial data supporting the approved indication.

Is V-OLET permanent?

Yes — the destroyed fat cells do not regenerate. Results are durable as long as significant weight gain does not cause remaining fat cells to enlarge.

How many sessions will I need?

Typically 3-5 sessions spaced 4 weeks apart. The dermatologist reassesses after each session, as individual fat distribution and response vary significantly.

Notice

Tell the dermatologist at consultation if any of the following apply.

Pregnancy or lactation
Active infection or inflammation in the submental treatment area
History of dysphagia (difficulty swallowing)
Prior submental or neck surgery distorting anatomical landmarks (relative — requires assessment)
Bleeding disorders or anticoagulant therapy (relative — requires review)

For your visit

Expected post-procedure swelling lasts 1-3 weeks — this is an expected biological response from fat cell destruction, not a complication
Avoid heat exposure (sauna, hot baths), strenuous exercise, and alcohol for 1 week
3-5 sessions at 4-week intervals are typically required for optimal results

References

The clinical claims on this page — device specs, efficacy timelines, safety profile — are supported by the primary sources below. Each citation links to the original paper or regulatory record.2 refs

[1]REFINE-1: Phase 3 RCT of ATX-101 (deoxycholic acid) for Submental Fat Reduction. Dermatol Surg (Jones DH et al.) — deoxycholic acid mechanism evidence; V-OLET shares the same active (2016).
[2]ATX-101 for Reduction of Submental Fat: A Phase 3 Randomized Controlled Trial (REFINE-2). J Am Acad Dermatol (Humphrey S et al.) — pivotal deoxycholic acid trial, MRI-confirmed volume reduction (2016).

Reviewed byDr. SangYoul Yun· Board-Certified Dermatologist · AAD International Fellow (IFAAD)· Last reviewed 2026-05-29

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Notice: Individual results may vary depending on skin condition, treatment history, and recovery factors. All treatment plans are determined through individual consultation with a board-certified dermatologist. The information on this page is for reference only and does not constitute medical advice or guarantee specific outcomes.

Next Step

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